Severe weather warnings have been issued for the Western Cape, Northern Cape, and Eastern Cape.
They are in place until Tuesday as multiple cold fronts hit the region.
An Orange Level 8 alert for disruptive rainfall is in place for Stellenbosch, Drakenstein, Theewaterskloof, Breede Valley, and Witzenberg.
These areas may see rainfall between 200 to 300 mm, creating a high risk of mudslides, dangerous fast-flowing rivers, and road flooding.
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An Orange level 6 warning has also been issued for Cape Town, the West Coast, Cape Winelands, and the Overberg.
At the same time, aid organisation Gift of the Givers is continuing relief operations in the Southern Cape and Eastern Cape, where flooding has affected thousands.