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Iranian state television confirmed the death of Iran's supreme leader Ayatollah Ali Khamenei on Sunday, after US President Donald Trump said he had been killed.

President Cyril Ramaphosa has expressed deep concern over rising tensions in the Middle East, warning that the escalating situation could threaten both regional and global stability.

Two witnesses told AFP they heard an explosion and saw a plume of smoke rising from Dubai's famed man-made island The Palm as authorities reported four injured.

Several international flights to and from South Africa have been suspended as the world's busiest airport has shut down.

The United States and Israel launched strikes against Iran on Saturday, sending columns of smoke rising over Tehran as the Islamic republic retaliated with barrages of missiles across the region.