The meeting at the Stade de France offers Fabien Galthie's side a chance for revenge for the loss two years ago, which denied them a shot at World Cup glory on home soil.
Should the 31-year-old Weatherald pad up against Ben Stokes's England, he will be the sixth opening partner for Usman Khawaja since David Warner retired last year.
The San Siro is one of the world's most recognisable stadiums and the longtime home of Inter and AC Milan, who between them have been crowned European champions 10 times.