Manchester United face Chelsea on Sunday with interim manager Ruud van Nistelrooy at the helm while faltering Arsenal face a potentially tricky trip to Newcastle.
Ruben Amorim says Manchester United told him it was "now or never" after being handed a brief midway through the season to restore the Premier League giants to the pinnacle of English and European football.
Who starts at fly-half and scrum-half will command most attention when world champions South Africa launch a three-Test tour of Britain on November 10 against Scotland in Edinburgh.